A pain-free way of tackling dental decay Researchers in the University of Leeds have discovered a pain-free way of tackling teeth decay that reverses the damage of acid strike and re-builds teeth as new. The pioneering treatment promises to transform the method of filling teeth forever. Tooth decay starts when acid made by bacterias in plaque dissolves the mineral in the teeth, causing microscopic holes or ‘pores’ to form. As the decay procedure progresses these micro-pores upsurge in size and number. Eventually the damaged tooth may need to be drilled and packed to prevent toothache, or also removed.Independent statisticians at Axio Research ready the interim unblinded reports for the independent data and basic safety monitoring committee, which oversaw patient basic safety and the quality of trial conduct. The full data set was transferred to Brigham and Women’s Hospital at study completion. The statistical analysis was performed by the sponsor and verified by the independent group at Brigham and Women’s Hospital. Run-in Period, Randomization, and Follow-up Eligible individuals entered a 4-to-12-week screening period and were subsequently randomly assigned to receive aliskiren or placebo furthermore to standard treatment and were followed for a median of 32.9 months, as described in detail in the Methods section in the Supplementary Appendix.