Obtain complete blood counts every 2 weeks for the first three months and then regular monthly or as clinically indicated, and adjust the dosage as recommended. Tumor Lysis Syndrome: Two patients with advanced disease treated with Iclusig developed serious tumor lysis syndrome. Hyperuricemia occurred in 7 percent of patients general; almost all had CP-CML . Ensure adequate hydration and deal with high uric acid amounts to initiating therapy with Iclusig prior. Compromised Wound Healing and Gastrointestinal Perforation: Since Iclusig may compromise wound curing, interrupt Iclusig for at least 1 week ahead of major surgery. Critical gastrointestinal perforation happened in one patient 38 days post-cholecystectomy. Embryo-Fetal Toxicity: Iclusig could cause fetal harm. If Iclusig is used during pregnancy, or if the patient becomes pregnant while taking Iclusig, the patient should be apprised of the potential hazard to the fetus.Medical analysis has found that, if still left untreated, those individuals who are obese will likely remain obese currently. However, not all weight-loss treatments are effective over the future – as a preponderance of data, published literature and scientific analysis have found that exercise and diet is unsuccessful in 80-85 percent of sufferers at one year. Related StoriesAustralian experts define key characteristics of metabolically healthy obeseThree out of four consumers not really covered for evidence-based weight problems treatment servicesSt. Michael's Hospital research finds that cholesterol-reducing diet plan also lowers blood circulation pressure As a doctor, I see patients each day who have been obese for years and also have tried several exercise and diet programs without success, said Robert Michaelson, M.D., Ph.D., Northwest Surgical Weight Loss Surgery, Everett, Washington, and Clinical Trial Investigator.