Secondary objectives consist of characterization of plasma and urine pharmacokinetics of ALN-TTR01 and evaluation of pharmacodynamic activity based on measurements of circulating TTR serum levels. RNAi therapeutics represent a novel and thrilling approach for the treatment of ATTR. Indeed, based on our knowledge of the individual genetics of this disease, this novel modality provides an encouraging therapeutic technique, said Teresa Coelho, M.D., Director, Unidade Clinica de Paramiloidose. Located in Porto, Portugal where she treats several hundred sufferers with the disease, Dr. Coelho can be an renowned expert in ATTR internationally. She added, The pre-medical data with ALN-TTR01 obtained to day are promising, especially recent results showing regression of pathogenic TTR tissue deposition in the mouse transgenic model.Delirium affected 606 patients during their medical center stay, with a median period of delirium of 4 days. Between enrollment and the 3-month follow-up, 252 patients died; 448 of the 569 surviving patients underwent cognitive screening three months after discharge. Another 59 individuals died before the 12-month follow-up, and 382 of the 510 surviving patients were tested 12 months after discharge . Intensity and Prevalence of Long-Term Cognitive Impairment Median RBANS global cognition scores at 3 and 12 weeks were 79 and 80 , respectively.