Research End Points The principal end point was the first occurrence of a composite cardiovascular outcome. Initially, the composite result included death from cardiovascular causes, nonfatal myocardial infarction, and nonfatal stroke, and the anticipated maximal follow-up period was 11.5 years. Through the first 2 years of the trial, the primary-event price in the control group was less than anticipated.9 Therefore, hospitalization for angina was added to the primary outcome, and planned follow-up was extended to a maximum of 13.5 years. Three composite secondary cardiovascular outcomes were also examined: death from cardiovascular causes, nonfatal myocardial infarction, or non-fatal stroke ; loss of life from any trigger, myocardial infarction, stroke, or hospitalization for angina; and loss of life from any trigger, myocardial infarction, stroke, hospitalization for angina, coronary-artery bypass grafting, percutaneous coronary intervention, hospitalization for heart failure, or peripheral vascular disease.Many people think that excessive toxins within your body are responsible for causing and building acne worse partly. Vegetables and Fruits are very good at cleansing your internal pipes. Green Drinks: Green drinks are simply just whole food concentrates that you generally mix with some drinking water before drinking. The benefit of a green drink is definitely that it is abundant with green foods that are alkaline and have the effect of neutralizing and cleansing your internal systems which as discussed above can help reduce your acne. Meditation: Reducing stress is an important component of any natural acne treatment program. Many people believe that stress could make acne worse. Meditation is one of the best ways to reduce stress. A simple meditation exercise is to concentrate on the breath.