We believe APD403 is a good anti-vomiting agent and a fantastic anti-nauseant, thereby getting the potential to create a significant contribution to cancers care.’ APD403 provides the presently marketed dopamine D2 /D3 antagonist amisulpride for the new, patent-protected, use of administration of CINV. The active ingredient can be being developed as APD421 for the prevention of post-operative nausea & vomiting , with two pivotal Phase III clinical studies recently having been initiated.. Acacia Pharma starts APD403 Phase II study to prevent chemotherapy-induced nausea & vomiting Acacia Pharma, a pharmaceutical organization specialising in the advancement of drugs for supportive care, announces the initiation of a Stage II research of APD403 in preventing chemotherapy-induced nausea & vomiting .Development in the quarter was driven by world-wide pharmaceutical sales, which increased 22.5 %, like the contribution from the Piramal and Solvay acquisitions, as well as worldwide vascular products sales, which increased 13.7 %. Diluted earnings per talk about, excluding specified products, were $1.30, reflecting 10.2 % growth. Diluted income per talk about under Generally Recognized Accounting Principles were $0.92, primarily reflecting costs connected with recently announced restructuring actions for the integration of the Solvay Pharmaceuticals acquisition and in procedure R&D related to the Reata collaboration. 4th quarter results included strong expense spending, with an elevated level of R&D spending, along with an adjusted gross margin ratio of 60.6 %, which increased 230 basis points over the last year.