Neither therapy got a substantial effect on the primary composite outcome of loss of life, cardiac tamponade needing pericardiocentesis, or constrictive pericarditis. With regards to the secondary outcomes, adjunctive prednisolone therapy reduced the incidence of constrictive pericarditis and the incidence of hospitalizations. However, both interventions increased the incidence of tumor among trial participants. Prior trials of adjunctive glucocorticoid therapy in individuals with tuberculous pericarditis had relatively little samples and included few HIV-infected patients, and there is poor reporting of adverse events.10,29-34 Our trial included 1400 individuals, a considerable number of whom had HIV infection.Induction Therapy Of the 582 eligible patients, 372 had a complete remission: 168 of 293 patients in the standard-dose group and 204 of 289 in the high-dose group . Among patients in both study groups who had a comprehensive remission, 121 of 168 in the standard-dosage group and 170 of 204 in the high-dosage group had a complete remission after one cycle of induction treatment. Of the 125 patients in the standard-dose group who did not have a reply to treatment, 76 had one cycle and 49 had two cycles of induction treatment. Among 85 similar patients in the high-dose group, 56 had one cycle and 29 had two cycles of induction therapy. Adverse Events There have been no significant differences in the rates of grade three to five 5 hematologic and nonhematologic toxic effects between your two study groups .