Siblings, by contrast, had less marked negative correlations in the frontal and subcortical regions, and an urgent positive correlation for the salience network. The distinctions between sufferers and siblings in the salience network mostly involved connections between the insula and section of the orbitofrontal cortex . Licensed from medwireNews with permission from Springer Health care Ltd. All rights reserved. Neither of these parties endorse or suggest any commercial products, services, or equipment.. Adolescent brain remodeling goes awry in schizophrenia By Eleanor McDermid, Senior medwireNews Reporter An essential reorganization process occurring in the adolescent human brain could be disturbed in those that go on to build up schizophrenia, a scholarly study suggests.One limitation of our study may be the nonrandomized design, resulting in potential confounding of the association between contraceptive technique and outcomes by characteristics associated with the choice of contraception. Furthermore, study participants were a chosen group . Insofar as women could be more likely to regularly use a way they have chosen than one they have already been assigned, the compliance rates may be higher, and failure rates lower, than would be expected in a randomized trial. Another potential limitation of our study is generalizability. Individuals were at high risk for unintended pregnancy and had to be willing to switch to a new contraceptive method, which may have resulted in overestimation of contraceptive failure rates, as compared with rates in the general U.S.